Brian Flemming from Michigan was obese, depressed and addicted to alcohol. He met Englishwoman Jackie Eastham via the drawing game app Draw Something in 2012. Eastham suffers myotonic muscular dystrophy, a debilitating condition that she manages by living an extremely healthy lifestyle. With her encouragement, Flemming quit drinking and began eating well and exercising. In just over a year he has lost 365lb – more than half his body weight. The pair met in Europe in December 2013 and climbed to the top of the Eiffel Tower together! What a great story!